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. 2021 Aug 23;10(2):919–940. doi: 10.1007/s40120-021-00273-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 1 — Markov-based model. ^aNot all transitions shown in the model structure were included in the base-case analysis. The included transitions were based on the selected natural history data. Transitions between AD severity levels were assumed to be independent of the care setting (i.e., community vs. institutional). ^bTransitions to death could occur from all other health states. AD Alzheimer's disease, MCI mild cognitive impairment