Fig. 3.

12-week changes in MDS-UPDRS Part II item scores: LS mean (95% CI) [Gocovri-placebo] treatment differences (pooled mITT population). P values are based on the comparison between Gocovri vs. placebo from the MMRM model with change from baseline as the dependent variable and the baseline value as a covariate. The model includes categorical effects for treatment group, study, and visit (weeks 2, 8, and 12), and the interaction between treatment group and visit. LS least squares, MDS-UPDRS Movement Disorder Society Unified Parkinson’s Disease Rating Scale, M-EDL motor aspects of experiences of daily living, mITT modified intent to treat, MMRM mixed-effects model repeated measure