Table 2.
Percentages of participants shifting from problematic to nonproblematic scores at week 12 and vice versa
| M-EDL item | Participants with problematic score at baseline, n | Improved to nonproblematic score at week 12, n/N (%) | Participants with nonproblematic score at baseline, n | Decline to problematic score at week 12, n/N (%) | ||||
|---|---|---|---|---|---|---|---|---|
| Placebo (n = 87) | Gocovri (n = 82) | Placebo (n = 87) | Gocovri (n = 82) | Placebo (n = 87) | Gocovri (n = 82) | Placebo (n = 87) | Gocovri (n = 82) | |
| Speech | 42 | 35 | 20/42 (47.6) | 17/35 (48.6) | 45 | 47 | 10/45 (22.2) | 6/47 (12.8) |
| Saliva and drooling | 37 | 35 | 11/37 (29.7) | 17/35 (48.6) | 50 | 47 | 7/50 (14.0) | 5/47 (10.6) |
| Chewing and swallowing | 4 | 5 | 4/4 (100.0) | 4/5 (80.0) | 83 | 77 | 3/83 (3.6) | 0/77 (0.0) |
| Eating tasks | 23 | 24 | 13/23 (56.5) | 19/24 (79.2) | 64 | 58 | 7/64 (10.9) | 4/58 (6.9) |
| Dressing | 29 | 26 | 15/29 (51.7) | 14/26 (53.8) | 58 | 56 | 4/58 (6.9) | 7/56 (12.5) |
| Hygiene | 10 | 7 | 6/10 (60.0) | 5/7 (71.4) | 77 | 75 | 2/77 (2.6) | 4/75 (5.3) |
| Handwriting | 44 | 42 | 9/44 (20.5) | 15/42 (35.7) | 43 | 40 | 11/43 (25.6) | 13/40 (32.5) |
| Hobbies | 39 | 42 | 20/39 (51.3) | 26/42 (61.9) | 48 | 40 | 9/48 (18.8) | 6/40 (15.0) |
| Turning in bed | 22 | 13 | 3/22 (13.6) | 5/13 (38.5) | 65 | 69 | 2/65 (3.1) | 3/69 (4.3) |
| Tremor | 28 | 33 | 7/28 (25.0) | 24/33 (72.7) | 59 | 49 | 12/59 (20.3) | 3/49 (6.1) |
| Getting out of bed/car/deep chaira | 38 | 34 | 14/38 (36.8) | 21/34 (61.8) | 49 | 47 | 9/49 (18.4) | 2/47 (4.3) |
| Walking and balance | 30 | 35 | 8/30 (26.7) | 12/35 (34.3) | 57 | 47 | 5/57 (8.8) | 3/47 (6.4) |
| Freezing | 35 | 26 | 6/35 (17.1) | 14/26 (53.8) | 52 | 56 | 5/52 (9.6) | 0/56 (0.0) |
Problematic means an item score of ≥ 2, and nonproblematic means an item score of 0 or 1, based on a score of 2 being the threshold at which symptoms have at least a modest impact on function [6]
M-EDL motor aspects of experiences of daily living
an = 81