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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Maturitas. 2021 Sep 5;154:13–19. doi: 10.1016/j.maturitas.2021.09.002

Table 1.

Mean on-trial endometrial thickness (mm) by treatment group in intention to treat population and per protocol population

Population Least square mean (95% CI) Time p Treatment p
Oral E2 plus Vaginal P4 Placebo
Intention to treat population
(430 women N=2105)		 3.03 (2.83, 3.22) 1.60 (1.52, 1.72) 0.54 <0.001
Per protocol population
(366 women N=1619)		 3.13 (2.89,3.35) 1.57 (1.46, 3.35) 0.67 <0.001

Least square means were estimated from a mixed effect linear model, including post-randomization values.

Time*Treatment interaction in ITT population p=0.17, PP population p=0.29

N=number of endometrial thickness measures, CI=confidence interval, E2=estradiol, P4=progesterone