REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Brilliant Violet 421™ anti-human CD3 (OKT3)	Biolegend	Cat# 317344; RRID:AB_2565849
Brilliant Violet 510™ anti-human CD8 (SK1)	Biolegend	Cat# 344732; RRID:AB_2564624
FITC anti-human HLA-DR (LN3)	Biolegend	Cat# 327006; RRID:AB_893569
PE anti-human CD 197 (CCR7) (G043H7)	Biolegend	Cat# 353204; RRID:AB_10913813
PerCPCy5.5 anti human CD4 (RPA-T4)	Biolegend	Cat# 300530; RRID:AB_893322
PE/Cy7 anti human CD45RA (HI100)	Biolegend	Cat# 304126; RRID:AB_10708879
APC anti-human CD38 (HB-7)	Biolegend	Cat# 356606; RRID:AB_2561902
PE anti-human CD183 (CXCR3) (G025H7)	Biolegend	Cat# 353706; RRID: AB_10962912
PE/Cy7 anti-human CD196 (CCR6) (G034E3)	Biolegend	Cat# 353418; RRID:AB_10916518
APC anti-human CD194 (CCR4) (L291H4)	Biolegend	Cat# 359408; RRID:AB_2562429
Brilliant Violet 421™ anti-human FOXP3 (206D)	Biolegend	Cat# 320124; RRID:AB_2565972
Brilliant Violet 510™ anti-human CD3 (SK7)	Biolegend	Cat# 344828; RRID:AB_2563704
PE anti-human CD279 (PD-1) (EH12.2H7)	Biolegend	Cat# 329906; RRID:AB_940483
PerCP/Cyanine5.5 anti-human IFN-γ (4S.B3)	Biolegend	Cat# 502526; RRID:AB_961355
APC anti-human CD57 (HNK-1)	Biolegend	Cat# 359610; RRID:AB_2562757
Brilliant Violet 421™ anti-human CD185 (CXCR5) (J252D4)	Biolegend	Cat# 356920; RRID:AB_2562303
PE anti-human CD25 (M-A251)	Biolegend	Cat# 356104; RRID:AB_2561861
APC anti-human CD127 (IL-7Rα) (A019D5)	Biolegend	Cat# 351316; RRID:AB_10900804
APC/Cyanine7 anti-human CD8a (RPA-T8)	Biolegend	Cat# 301016; RRID:AB_314134
Brilliant Violet 421™ anti-human CD366 (Tim-3) (F38-2E2)	Biolegend	Cat# 345008; RRID:AB_11218598
FITC anti-human CD223 (LAG-3) (11C3C65)	Biolegend	Cat# 369308; RRID:AB_2629751
PE anti-human KLRG1 (MAFA) (SA231A2)	Biolegend	Cat# 367712; RRID:AB_2572157
APC anti-human CD152 (CTLA-4) (BNI3)	Biolegend	Cat# 369612; RRID:AB_2632874
APC-Vio® 770 anti-human CD4 (VIT4)	Miltenyi Biotec	Cat# 130-096-652; RRID:AB_2660925
VioGreen® CD8 anti-human (BW135/80)	Miltenyi Biotec	Cat# 130-096-902; RRID:AB_2660905
VioGreen® CD20 anti-human (REA780)	Miltenyi Biotec	Cat#: 130-111-532; RRID:AB_2656069
VioGreen® CD14 anti-human (Tük4)	Miltenyi Biotec	Cat# 130-096-875; RRID:AB_2660175
FITC CD154 anti-human (5C8)	Miltenyi Biotec	Cat# 130-096-233; RRID:AB_10830229
CD40 Antibody, anti-human, pure-functional grade (HB14)	Miltenyi Biotec	Cat# 130-094-133; RRID:AB_10839704
Alexa Fluor® 488 Anti-CPT1A (8F6AE9)	abcam	Cat# ab171449; RRID:AB_2714024
Anti-IDH2 (EPR7577)	abcam	Cat# ab230796
Anti-Hexokinase 1 (EPR10134(B))	abcam	Cat# ab233837
Anti-Glucose 6 Phosphate Dehydrogenase (EPR6292)	abcam	Cat# ab231828
Anti-Peroxiredoxin 2/PRP (EPR5154)	abcam	Cat# ab227988
PE Anti-Glucose Transporter GLUT1 (EPR3915)	abcam	Cat# ab209449
Alexa Fluor® 700 anti-human CD3 (SK7)	Biolegend	Cat# 344822; RRID:AB_2563420
Brilliant Violet 421™ anti-human CD14 (HCD14)	Biolegend	Cat# 325628; RRID:AB_2563296
Brilliant Violet 510™ anti-human CD19 (HIB19)	Biolegend	Cat# 302242; RRID:AB_2561668
BUV395 Mouse anti-human CD4 (SK3 (Leu3a))	BD Biosciences	Cat# 563552; RRID:AB_2738275
APC-eFluor 780 anti-human CD8a (SK1)	ThermoFisher Scientific	Cat# 47-0087-42; RRID:AB_2016684
Brilliant Violet 785™ anti-human CD56 (NCAM) (5.1H11)	Biolegend	Cat# 362550; RRID:AB_2566059
Brilliant Violet 650™ anti-human CD45RO (UCHL1)	Biolegend	Cat# 304232; RRID:AB_2563462
Brilliant Violet 605™ anti-human CD62L (DREG-56)	Biolegend	Cat# 304834; RRID:AB_2562130
Chemicals, peptides, and recombinant proteins
PepTivator® EBV EBNA-1, human	Miltenyi Biotec	Cat# 130-093-613
PepTivator® EBV LMP2A, human	Miltenyi Biotec	Cat# 130-093-615
PepTivator® EBV BZLF1, human	Miltenyi Biotec	Cat# 130-093-611
Human AB serum	Sigma Aldrich	Cat# H4522
Brefeldin A	Sigma Aldrich	Cat# B5936
Sodium pyruvate	Thermo Fisher Scientific	Cat# BP356-100
L-Glutamine	Thermo Fisher Scientific	Cat# 25030081
Glucose	Sigma Aldrich	Cat# G7528
Methyl tert-butyl ether (MTBE)	Biosolve Chemicals	Cat# 13890602
Derivatization reagents for GC (MSTFA)	Macherey-Nagel	Cat# 701270.510
ULC/MS grade Acetonitrile	Biosolve Chemicals	Cat# 01204102
Acetic acid glacial ULC/MS	Biosolve Chemicals	Cat# 01074131
ULC/MS grade Water	Biosolve Chemicals	Cat# 23214102
Critical commercial assays
Seahorse XF Cell Mito Stress Test Kit	Agilent Technologies	Cat# 103015-100
Seahorse XF Base Medium	Agilent Technologies	Cat# 102353-100
Seahorse Calibrant Solution	Agilent Technologies	Cat# 100840-000
Seahorse XFe96 FluxPak	Agilent Technologies	Cat# 102416-100
RNeasy Plus Mini Kit	Qiagen	Cat# 74134
RevertAid H Minus First Strand cDNA Synthesis Kit	Thermo Fisher Scientific	Cat# K1632
TaqMan® Gene Expression Assay	Thermo Fisher Scientific	Cat# 4331182
CD154 MicroBead Kit, human	Miltenyi Biotec	Cat# 130-092-658
CD3 MicroBeads, human	Miltenyi Biotec	Cat# 130-050-101
CD14 MicroBeads, human	Miltenyi Biotec	Cat# 130-050-201
LS columns	Miltenyi Biotec	Cat# 130-042-401
MS columns	Miltenyi Biotec	Cat# 130-042-201
LIVE/DEAD® Fixable Aqua Dead Cell Stain Kit	Thermo Fisher Scientific	Cat# L34957
Zombie UV™ Fixable Viability Kit	Biolegend	Cat# 423107
Zombie NIR™ Fixable Viability Kit	Biolegend	Cat# 423106
Fixation/Permeablization Kit	BD Biosciences	Cat# 554714; RRID:AB_2869008
eBioscience™ Foxp3 / Transcription Factor Staining Buffer Set	ThermoFisher Scientific	Cat# 00-5523-00
PE/Cy7® Conjugation Kit - Lightning-Link®	abcam	Cat# ab102903
PerCP/Cy5.5® Conjugation Kit - Lightning-Link®	abcam	Cat# ab102911
PE/Atto 594 Conjugation Kit - Lightning-Link®	abcam	Cat# ab269900
Alexa Fluor® 647 Conjugation Kit (Fast) - Lightning-Link®	abcam	Cat# ab269823
Software and algorithms
BD FACSDiva version 6.1.2	BD Biosciences	RRID:SCR_001456
FlowJo 10.1	Treestar Inc., USA	RRID:SCR_008520
GraphPad Prism 7	GraphPad Software Inc., USA	RRID:SCR_002798
Wave Desktop 2.3	Agilent Technologies	RRID:SCR_014526
R Version 4.0.5	R Project for Statistical Computing	RRID:SCR_001905
Leco Chroma-TOF-GC Software v4.50.8.0	LECO	N/A; https://www.leco.com/product/chromatof-software
Python Programming Language 3.8.5	http://www.python.org/	RRID:SCR_008394
MatPlotLib 3.3.1	http://matplotlib.sourceforge.net	RRID:SCR_008624
NumPy 1.19.1	http://www.numpy.org	RRID:SCR_008633
Pandas 1.1.3	https://pandas.pydata.org	RRID:SCR_018214
SciPy 1.5.2	http://www.scipy.org/	RRID:SCR_008058
Seaborn 0.11.0	https://seaborn.pydata.org/	RRID:SCR_018132
Statsmodel 0.12.0	http://www.statsmodels.org/	RRID:SCR_016074
Other
ACQUITY UPLC HSS T3 Column	Waters	Cat# 176001132
ACQUITY UPLC BEH C8 Column	Waters	Cat# 176000885