Fig. 1.

Overview of samples.

5916 tumor samples from 5387 patients with LUAD were collected. Targeted deep sequencing was performed on 4677 tumor samples, including 3743 from primary tumors and 934 from metastases. Immunohistochemistry assays were performed on 1588 tumor samples, including 1336 from primary tumors and 252 from metastases. Abbreviations: MT – metastatic tumor, PT – primary tumor, TMB – tumor mutational burden.