Fig. 3.

Metastasis-enriched alterations.

The odds ratio and p value for the comparison of prevalence in primary tumors and metastases of each alteration are shown. P values were adjusted for false discovery rates (q values). Each scatter denotes an alteration. Alteration scatters with P < 0.05 in pleural metastases or q < 0.2 at other metastatic sites are colored and enlarged. Five mutations with the smallest q values, five copy number variations with the smallest q values, and all gene fusions with P < 0.05 were labeled black and displayed in the schematic diagram at the center. Alterations that were enriched in primaries were additionally labeled blue. Pleural metastases showed a total of only 6 alterations that had P < 0.05. Abbreviations: MT – metastatic tumor, PT – primary tumor, OR – odds ratio, SNV – single nucleotide variation, CNV – copy number variation.