REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-myc	Cell Signaling	Clone 71D10, Cat #2278
Anti-GAPDH	Cell Signaling	Clone 14C10, Cat #2118
Anti-pSTAT3 (pTyr705)	Cell Signaling	Clone D3A7, Cat#9145
Anti-STAT3	Cell Signaling	Clone 124H6, Cat#9139
Mouse-POD	Cell Signaling	Cat#7076
Rabbit-POD	Cell Signaling	Cat#7074
Bacterial and virus strains
E. coli DH5α	Invitrogen	Cat#18265-017
Chemicals, peptides, and recombinant proteins
HyperIL-6	(Fischer et al., 1997)	N/A
IL-6	(Mackiewicz et al., 1992)	N/A
IL-11	(Lokau et al., 2017b)	N/A
sgp130Fc WT	(Jostock et al., 2001)	N/A
sgp130Fc T102Y	Conaris Research AG	N/A
sgp130Fc Q113F	Conaris Research AG	N/A
sgp130Fc T102Y/Q113F	Conaris Research AG	N/A
sgp130Fc T102Y/Q113F/N114L	Conaris Research AG	N/A
sIL-6R	R&D Systems	Cat# 227-SR-025/CF
sIL-11R	R&D Systems	Cat# 8895-MR-050
Turbofect	Thermo Fisher Scientific	Cat# R0532
Ionomycin	Thermo Fisher Scientific	Cat# I24222
Tris-HCl	Carl Roth	Cat# 9090.3
Tris Base	Carl Roth	Cat# AE15.1
NaCl	Carl Roth	Cat# 9357.2
Methanol	Carl Roth	Cat# 4627.5
Tween-20	Carl Roth	Cat# 9127.1
TEMED	Carl Roth	Cat# 2367.1
Protease Inhibitor Cocktail	Sigma Aldrich	Cat# P8340
Acrylamide (Rotiphorese Gel 30)	Carl Roth	Cat# 3029.1
bovine serum albumin	Carl Roth	Cat# T844.3
Trichloracetic acid	Carl Roth	Cat# 8789.1
SDS	Carl Roth	Cat# 2326.2
β-mercaptoethanol	Carl Roth	Cat# 4227.3
EDTA	Carl Roth	Cat# 8043.2
Glycin	Carl Roth	Cat# 3908.3
Critical commercial assays
Cell Titer Blue Cell Viability Assay	Promega	Cat# G8080
SYBR Green Mastermix	Thermo Fisher Scientific	Cat# 4309155
Experimental models: Cell lines
Ba/F3-gp130	(Gearing et al., 1994)	N/A
HEK293	ATCC	RRID:CVCL_0045
Oligonucleotides
mSOCS3 F GCTCCAAAAGCGAGTACCAGC	Sigma-Aldrich	N/A
mSOCS3 R AGTAGAATCCGCTCTCCTGCAG	Sigma-Aldrich	N/A
mGAPDH F AAGGTCATCCCAGAGCTGAA	Sigma-Aldrich	N/A
mGAPDH R CTGCTTCACCACCTTCTTGA	Sigma-Aldrich	N/A
Recombinant DNA
pcDNA3.1	ThermoFisher Scientific	N/A
pcDNA3.1-Myc-hIL-6R	(Lokau et al., 2017c)	NA
pcDNA3.1-Myc-hIL-11R	(Lokau et al., 2017c)	N/A
Software and algorithms
UCSF Chimera 1.13.1	(Pettersen et al., 2004)	RRID:SCR_004097
Image Studio Lite Ver 5.2	Li-COR Biosciences	RRID:SCR_013715
GraphPad Prism 8	GraphPad Software Inc	RRID:SCR_002798