Table 3.
Perioperative parameters and clinical events in patients with and without late deterioration in renal function and univariate regression analysis for prediction of late deterioration in renal function.
| with LDRF (n = 14) | without LDRF (n = 55) | p value | Odds ratio | 95% CI | p value | |
|---|---|---|---|---|---|---|
| LVAD implantation - discharge | ||||||
| perioperative AKI (%) | 57.1 | 16.4 | 0.0028* | 6.8 | 1.90–24.43 | 0.0032* |
| Alb (mg/dL)(1) | 3.1 ± 0.5 | 3.2 ± 0.4 | 0.23 | 0.12 | 0.0035–3.89 | 0.22 |
| eGFR (mL/min/1.73 m2) (1) | 108.7 ± 45.8 | 96.4 ± 27.5 | 0.20 | 5.9 | 0.38–93.11 | 0.20 |
| T-bil (mg/dL)(1) | 0.9 ± 0.2 | 0.8 ± 0.2 | 0.29 | 4.4 | 0.28–69.48 | 0.30 |
| BNP (pg/mL)(1) | 310.4 [ 177.9–732.0] | 236.9 [143.2–395.9] | 0.23 | 11.3 | 0.76–168.65 | 0.079 |
| RAP (mmHg)(1) | 9.4 ± 4.4 | 7.8 ± 3.9 | 0.20 | 4.9 | 0.43–55.79 | 0.20 |
| PAWP (mmHg)(1) | 10.1 ± 5.7 | 8.4 ± 4.9 | 0.27 | 3.8 | 0.34–43.75 | 0.28 |
| Cardiac Index (L/min/m2)(1) | 2.5 ± 0.8 | 2.5 ± 0.5 | 0.94 | 0.8 | 0.025–31.36 | 0.94 |
| RVSWI (g·m/m2/beat)(1) | 3.6 ± 3.4 | 4.0 ± 1.8 | 0.61 | 0.4 | 0.0082–16.3 | 0.60 |
| PAPi(1) | 2.1 ± 1.4 | 2.1 ± 1.5 | 0.86 | 0.7 | 0.013–35.97 | 0.86 |
| Aortic valve opening (%)(1) | 50.0 | 34.5 | 0.29 | 1.9 | 0.58–6.2 | 0.29 |
| Events from discharge to 30 months after LVAD implantation | ||||||
| AKI (%)(2) | 35.7 | 23.6 | 0.37 | 1.8 | 0.51–6.31 | 0.36 |
| Pump thrombosis (%)(2) | 14.3 | 12.7 | 0.88 | 1.1 | 0.21–6.22 | 0.88 |
| AI (%)(2) | 57.1 | 18.9 | 0.0061* | 5.7 | 1.62–20.26 | 0.0061* |
| DLI (%)(2) | 28.6 | 43.6 | 0.30 | 0.52 | 0.14–1.85 | 0.31 |
| Stroke (%)(2) | 7.1 | 23.6 | 0.13 | 0.25 | 0.030–2.08 | 0.13 |
| VA (%)(2) | 57.1 | 21.8 | 0.012* | 4.8 | 1.39–16.46 | 0.013* |
| late RVF (%)(2) | 35.7 | 0 | <0.0001* | 6.7 × 107 | n/a | <0.0001* |
| RAASi at 30 months (%) | 42.8 | 60 | 0.25 | 0.5 | 0.15–1.64 | 0.25 |
*: Significantly different between with and without LDRF
(1): result at 1 month after LVAD implantation
(2): the incidence of each adverse event after discharge from hospital following the index LVAD implantation up to 30 months
(3): the degree of AI could not be estimated in two patients due to poor study.
LVAD; left ventricular assist device, LDRF; late deterioration in renal function, CI: confidence interval, AKI; acute kidney injury, Alb; albumin, T-bil; total-bilirubin, BNP; brain natriuretic peptide, RAP; right atrial pressure, PAWP; pulmonary artery wedge pressure, RVSWI; right ventricular stroke work index, PAPi; pulmonary artery pulsatility index, RAASi; renin-angiotensin-aldosterone system inhibitor, AI; aortic insufficiently, DLI; driveline infection, VA; ventricular arrhythmia, RVF; right ventricular failure