Table 2.
Health‐related quality of life changes from baseline
| Outcome, week | Real acupuncture (n = 27) | Sham acupuncture (n = 24) | Usual care (n = 24) | |||
|---|---|---|---|---|---|---|
| Mean (95% CI) | Change from baseline, mean (95% CI) | Mean (95% CI) | Change from baseline, mean (95% CI) | Mean (95% CI) | Change from baseline, mean (95% CI) | |
| FACT/GOG‐Ntx | ||||||
| 0 | 25.47 (23.66–27.28) | NA | 25.47 (23.66–27.28) | NA | 25.47 (23.66–27.28) | NA |
| 4 | 27.41 (25.07–29.74) | 1.93 (0.12 to 3.75) a | 27.51 (25.18–29.84) | 2.04 (0.24 to 3.84) a | 26.71 (24.31–29.11) | 1.24 (−0.65 to 3.13) |
| 8 | 29.49 (27.19– 31.78) | 4.02 (2.26 to 5.77) b | 28.71 (26.38–31.04) | 3.24 (1.44 to 5.04) b | 25.32 (22.91–27.72) | −0.15 (−2.05 to 1.75) |
| 12 | 29.17 (26.85– 31.48) | 3.69 (1.91 to 5.48) b | 29.68 (27.35–32.01) | 4.21 (2.41 to 6.01) b | 27.30 (24.92–29.68) | 1.83 (−0.03 to 3.70) c |
| HADS anxiety | ||||||
| 0 | 6.92 (5.94–7.89) | NA | 6.92 (5.94–7.89) | NA | 6.92 (5.94–7.89) | NA |
| 8 | 5.87 (4.62–7.11) | −1.05 (−2.01 to −0.09) a | 6.02 (4.76–7.28) | −0.90 (−1.88 to 0.08) c | 7.09 (5.80–8.38) | 0.17 (−0.85 to 1.20) |
| 12 | 5.70 (4.44–6.95) | −1.22 (−2.19 to −0.24) a | 5.86 (4.60–7.12) | −1.06 (−2.04 to −0.08) a | 6.48 (5.19–7.77) | −0.44 (−1.46 to 0.59) |
| HADS depression | ||||||
| 0 | 4.78 (3.92–5.63) | NA | 4.78 (3.92–5.63) | NA | 4.78 (3.92–5.63) | NA |
| 8 | 4.64 (3.52–5.77) | −0.13 (−1.05 to 0.79) | 3.43 (2.28–4.57) | −1.35 (−2.29 to −0.41) d | 5.13 (3.95–6.31) | 0.36 (−0.62 to 1.34) |
| 12 | 4.47 (3.33–5.61) | −0.30 (−1.24 to 0.63) | 4.42 (3.28–5.57) | −0.35 (−1.29 to 0.59) | 4.89 (3.71–6.07) | 0.11 (−0.87 to 1.09) |
| ISI | ||||||
| 0 | 11.89 (10.28–13.51) | NA | 11.89 (10.28–13.51) | NA | 11.89 (10.28–13.51) | NA |
| 8 | 9.78 (7.69–11.86) | −2.12 (−3.76 to −0.47) a | 9.73 (7.62–11.85) | −2.16 (−3.84 to −0.48) a | 10.38 (8.20–12.55) | −1.51 (−3.27 to 0.24) c |
| 12 | 9.71 (7.60–11.82) | −2.18 (−3.85 to −0.51) a | 9.69 (7.58–11.80) | −2.20 (−3.88 to −0.52) a | 10.52 (8.35–12.69) | −1.37 (−3.13 to 0.38) |
| BFI severity | ||||||
| 0 | 4.87 (4.30–5.44) | NA | 4.87 (4.30–5.44) | NA | 4.87 (4.30–5.44) | NA |
| 8 | 3.75 (2.87–4.63) | −1.12 (−1.98 to −0.27) a | 4.45 (3.55–5.35) | −0.42 (−1.29 to 0.45) | 4.68 (3.74–5.61) | −0.19 (−1.10 to 0.71) |
| 12 | 4.45 (3.56–5.35) | −0.42 (−1.29 to 0.45) | 4.22 (3.32–5.12) | −0.65 (−1.52 to 0.22) | 3.26 (2.33–4.20) | −1.61 (−2.52 to −0.70) b |
a
p < .05.
b
p < .001.
c
p < .10.
d
p < .01.
Abbreviations: BFI, Brief Fatigue Inventory; CI, confidence interval; FACT/GOG‐Ntx, Functional Assessment of Cancer Therapy/Gynecologic Oncology Group‐Neurotoxicity; HADS, Hospital Anxiety and Depression Scale; ISI, Insomnia Severity Index; NA, not applicable.