Extended Data Table 1.
Antibiotic susceptibility of M. abscessus isolates
| Months relative to phage treatment initiation | ||||||||
|---|---|---|---|---|---|---|---|---|
| Antibiotic 1 | −8 | 0 | 1 | 2 | 3 | 4 | 5 | 6 |
|
| ||||||||
| T rimethoprim/sulfamethoxazole | >8/152 | >8/152 | >8/152 | >8/152 | >8/152 | >8/152 | >8/152 | >8/152 |
| Ciprofloxacin | >4 | >4 | >4 | >4 | >4 | >4 | >4 | >4 |
| Moxifloxacin | >8 | >8 | >8 | >8 | >8 | >8 | >8 | >8 |
| Cefoxitin | 64 | 64 | 64 | 64 | 64 | 32 | 64 | 64 |
| Amikacin | 32 | 32 | 32 | 32 | 32 | 32 | 16 | 32 |
| Doxycycline | >16 | >16 | >16 | >16 | >16 | >16 | >16 | >16 |
| Tigecycline | 4 | 2 | 4 | 4 | 4 | 4 | 4 | 4 |
| Linezolid | 32 | 32 | 32 | 32 | 32 | >32 | >32 | >32 |
| Imipenem | 64 | 64 | 64 | 64 | >64 | 64 | >64 | >64 |
| Cefepime | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 |
| Amoxicillin/clavulanate | >64/32 | >64/32 | >64/32 | >64/32 | >64/32 | >64/32 | >64/32 | >64/32 |
| Ceftriaxone | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 |
| Minocycline | >8 | >8 | >8 | >8 | >8 | >8 | >8 | >8 |
| Tobramycin | >16 | >16 | >16 | >16 | >16 | >16 | >16 | >16 |
| Clarithromycin (3 days) | >16 | >16 | >16 | >16 | >16 | >16 | >16 | >16 |
| Clarithromycin (14 days) | >16 | >16 | >16 | >16 | >16 | >16 | >16 | >16 |
1
Antibiotic minimum inhibitory concentration (MIC) determination s (in μg/mL) active against M. abscessus GD82 were determined pre-phage therapy initiation and monthly during phage therapy using a standard antibiotic panel for rapidly growing mycobacteria (Sensititre RAPMYCO ™).