Figure 5.
Nanoparticle-enhanced radiotherapy to trigger robust cancer immunotherapy for metastasis prevention
(A) Antitumor immune response induced by PLGA-R837@Cat radiotherapy and checkpoint blockade to inhibit metastasis and recurrence.
(B) Inhibition of tumor metastasis by radiotherapy with PLGA-R837@Cat plus αCTLA4 therapy in a 4T1 orthotopic breast tumor metastasis model.
(C) Morbidity-free survival of different groups of mice with metastatic 4T1 tumors after various treatments. (∗ P < 0.05).
(D) In vivo bioluminescence images showing the spreading and growth of firefly luciferase-4T1 (fLuc-4T1) cancer cells in different groups of mice after eliminating their primary orthotopic tumors.
Reproduced with permission from Chen et al.110 Copyright 2019, Wiley-VCH.