Figure 7.

Nano-immunopotentiators Fe₃O₄-OVA promote cancer immunotherapy for preventing lung metastasis of melanoma

(A) Schematic illustration of the Fe₃O₄-OVA vaccination strategy. The Fe₃O₄-OVA vaccine composed of ultra-small Fe₃O₄ nanoparticles and OVA not only improved DC maturation and T cell activation but also showed a positive effect on macrophage activation, resulting in improved outcomes.

(B) In vivo bioluminescence imaging of the B16-OVA-luc lung metastasis in control and treated groups after 13 days of treatment (left), together with the representative images of lungs stained with H&E from mice intravenously injected with B16-OVA tumor cells and different treatments (right). Green arrows indicate the tumor areas. Scale bars, 500 μm. Inset: representative photographs of lungs from each group after 13 days of treatment.

Reproduced with permission from Luo et al.¹³² Copyright 2019, Elsevier.