Table 2.
Liver enzymes and lipid concentrations after start of hormone therapy
| No CPA | 10 mg CPA | 25 mg CPA | 50 mg CPA | 100 mg CPA | |
|---|---|---|---|---|---|
| Liver enzymes (SEM) | |||||
| AST, U/L | 21 (1) | 17 (2) | 19 (0) | 19 (0) | 18 (2) |
| ALT, U/L | 28 (2) | 21 (3) | 22 (0) | 22 (0) | 20 (3) |
| GGT, U/L | 22 (5) | 20 (10) | 27 (2) | 24 (1) | 22 (8) |
| ALP, U/L | 67 (2) | 61 (5) | 63 (1) | 61 (1) | 81 (18) |
| Lipid profile (SEM) | |||||
| LDL-C, mmol/L | 2.5 (0.1) | 2.2 (0.1) | 2.2 (0.0) | 2.4 (0.0) | 2.4 (0.1) |
| HDL-C, mmol/L | 1.4 (0.0) | 1.4 (0.1) | 1.2 (0.0) | 1.2 (0.0) | 1.2 (0.1) |
| Total cholesterol, mmol/L | 4.4 (0.1) | 4.0 (0.2) | 4.0 (0.0) | 4.0 (0.0) | 4.0 (0.1) |
| Triglycerides, mmol/L | 1.2 (0.0) | 0.9 (0.1) | 1.0 (0.0) | 1.0 (0.0) | 1.0 (0.1) |
Measurements are clustered within participants at 3 and 12 months of hormone therapy. Concentrations are presented as mean with standard error of the mean (SEM).
Abbreviations: ALP, alkaline phosphatase; ALT, alanine transaminase; AST, aspartate transaminase; BMI, body mass index; CPA, cyproterone acetate; GGT, gamma-glutamyl transferase; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.