Table 4.

Prevalence of the condition of low SHBG in sub-cohorts with various conditions, status, or diseases

	Participants without the specified condition, status, or disease (control)		Participants with the specified condition, status, or disease			P valueb
	Unweighted (n)	Weighted prevalencea (%)	Number, unweighted	Weighted prevalencea (%)	Change from control (%)
Hysterectomy	1508	2.7	420	3.2	19	<0.001
Oophorectomy	1702	2.5	207	4.8	92	<0.001
Pregnant	497	1.7	15	0.0	−100	<0.001
Breastfeeding	90	1.2	33	1.4	17	<0.001
Hispanic	2964	2.9	1129	3.7	28	<0.001
Non-Hispanic white	2502	3.3	1591	2.9	−12	<0.001
Non-Hispanic black	3335	3.1	758	2.2	−29	<0.001
Non-Hispanic other	3478	2.8	615	3.9	39	<0.001
Heart attack	3921	3.0	169	3.3	10	<0.001
Angina	3994	3.0	94	1.8	−40	<0.001
Congestive HF	3947	3.1	142	1.8	−42	<0.001
CHD	3911	3.0	171	3.2	7	<0.001
Stroke	3944	3.0	142	3.0	0	<0.001
Chronic bronchitis	3847	3.0	232	3.4	13	<0.001
COPD	3947	3.0	143	3.3	10	<0.001
Emphysema	4005	3.1	85	1.4	−55	<0.001
Liver disease	3903	3.0	184	3.6	20	<0.001
Kidney disease	3936	3.0	151	1.8	−40	<0.001
Thyroid disease	3633	2.9	456	4.1	41	<0.001
Cancer	3722	3.0	369	3.4	13	<0.001
HIV	2700	3.3	14	0.0	−100	<0.001
Arthritis	3013	2.9	1072	3.3	14	<0.001
HTN	2431	2.7	1598	3.4	26	<0.001
DM	3325	2.3	768	7.1	209	<0.001

Abbreviations: CHD, coronary heart disease; COPD, chronic obstructive pulmonary disease; DM, diabetes mellitus; HF, heart failure; HIV, human immunodeficiency virus disease; HTN, hypertension.

^aLow SHBG was defined as SHBG < 12.3 nmol/L in men < 50 years, <23.5nmol/L in men ≥ 50 years, <14.5nmol/L in women < 30 years, and <21.9nmol/L in women ≥ 30 years.

^bDifferences in the prevalence of low SHBG between those with and without the specified condition, status, or disease were analyzed using the weighted Pearson Chi-square test.