Table 5.
Odds ratios (95% CI) of various conditions, status, or diseases for low SHBG in 4061 participants analyzed by weighted multivariable binary logistic regression
| Men | Women | |||||
|---|---|---|---|---|---|---|
| ORa | 95% CI | P-value | ORa | 95% CI | P-value | |
| Pregnancy | NA | NA | NA | 0.00 | 0-1.4E+27 | 0.677 |
| Breastfeeding | NA | NA | NA | 1.94 | 1.91-1.97 | <0.001 |
| Parity(≥2 deliveries) | NA | NA | NA | 0.74 | 0.74-0.75 | <0.001 |
| Oophorectomy | NA | NA | NA | 2.13 | 2.13-2.14 | <0.001 |
| Age, y | 1.02 | 1.02-1.02 | <0.001 | 0.98 | 0.98-0.98 | <0.001 |
| Ethnicity | ||||||
| Hispanic | 1.00 | 1.00 | ||||
| Non-Hispanic white | 0.65 | 0.64-0.65 | <0.001 | 1.08 | 1.08-1.08 | <0.001 |
| Non-Hispanic black | 0.76 | 0.76-0.76 | <0.001 | 0.43 | 0.43-0.44 | <0.001 |
| Non-Hispanic other | 1.59 | 1.58-1.60 | <0.001 | 2.19 | 2.18-2.20 | <0.001 |
| Ln [BMI (kg/m2)] | 13.75 | 13.67-13.83 | <0.001 | 21.11 | 20.99-21.22 | <0.001 |
| Physically active | 0.68 | 0.68-0.68 | <0.001 | 1.07 | 1.06-1.07 | <0.001 |
| Smoker | 1.02 | 1.02-1.02 | <0.001 | 1.43 | 1.43-1.44 | <0.001 |
| Alcohol drinker | 1.90 | 1.89-1.91 | <0.001 | 0.92 | 0.91-0.92 | <0.001 |
| Heart attack | 1.63 | 1.62-1.64 | <0.001 | 0.00 | 0-1.4E+11 | 0.425 |
| Angina | 0.47 | 0.46-0.47 | <0.001 | 1.99 | 1.97-2.02 | <0.001 |
| Congestive HF | 0.28 | 0.28-0.28 | <0.001 | 0.64 | 0.63-0.65 | <0.001 |
| CHD | 1.68 | 1.67-1.69 | <0.001 | 1.27 | 1.26-1.28 | <0.001 |
| Stroke | 0.94 | 0.93-0.95 | <0.001 | 1.01 | 1.00-1.02 | 0.038 |
| Chronic bronchitis | 0.36 | 0.36-0.36 | <0.001 | 1.05 | 1.04-1.05 | <0.001 |
| COPD | 1.77 | 1.76-1.78 | <0.001 | 1.23 | 1.22-1.24 | <0.001 |
| Emphysema | 0.29 | 0.28-0.29 | <0.001 | 0.28 | 0.27-0.28 | <0.001 |
| Liver condition | 1.06 | 1.05-1.06 | <0.001 | 0.44 | 0.44-0.44 | <0.001 |
| Kidney disease | 0.81 | 0.81-0.82 | <0.001 | 0.12 | 0.11-0.12 | <0.001 |
| Thyroid disease | 0.6 | 0.6-0.61 | <0.001 | 2.41 | 2.40-2.41 | <0.001 |
| Cancer | 3.22 | 3.21-3.23 | <0.001 | 0.53 | 0.53-0.53 | <0.001 |
| HIV | 0.00 | 0-2.4E+39 | 0.749 | 0.00 | 0-2.9E+167 | 0.938 |
| Arthritis | 0.79 | 0.79-0.79 | <0.001 | 0.71 | 0.71-0.71 | <0.001 |
| DM | 2.65 | 2.64-2.65 | <0.001 | 3.49 | 3.49-3.51 | <0.001 |
| HTN | 0.46 | 0.46-0.46 | <0.001 | 1.40 | 1.39-1.40 | <0.001 |
Abbreviations: CHD, coronary heart disease; COPD, chronic obstructive pulmonary disease; DM, diabetes mellitus; HF, heart failure; HIV, human immunodeficiency virus disease; HTN, hypertension; Ln [BMI (kg/m2)], natural log-transformed body mass index (kg/m2); NA, not applicable; OR, odds ratio.
aOR of the absence of the specified condition, status, or disease for low SHBG was regarded as 1.