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. 2021 Nov 6;9:38. doi: 10.1186/s40170-021-00267-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — CEST spectra of the Yb₃ complex (10 mM) containing 3353T3 cancer cell-cultured media which were obtained via incubation cells with 5 mM methylglyoxal (MG) in DMEM basal media (4 h at 37°C, pH ~ 7.0). The CEST peak at 165 ppm reflects d-lactate while the peak at 154 ppm reflects l-lactate in each cell line. Glo1 re-expressed cells, sgGlo1 pLHCX (black), Glo1 deleted cells, sgGlo1 (blue), and parental cells (red)