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. 2021 Nov 5;12:25. doi: 10.1186/s13100-021-00253-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Allelic variants of the Tn5253 attB integration site in S. pneumoniae. Tn5253 attB is located in the essential pneumococcal rbgA gene. In the 85 complete S. pneumoniae genomes, 13 allelic variants of attB were found. The 83-bp variant 1 (attB1) is the most frequent, carried by 38 genome strains (44.7 % of the analyzed genomes), including D39 strain, its rough derivative R6, and A66 strain, and was used as reference for the alignment. Variant 2 is carried by TIGR4 and other 8 genome strain and contains 2 nucleotide substitutions. BM6001, the original Tn5253-carrying clinical strain, and DP1322, in which Tn5253 was transferred by transformation from BM6001, harbour variant 5. SP18-BS74, whose draft genome is available, harbours the 41-bp variant 13. Within the sequences, identical nucleotides are indicated by periods, substitutions in red. For better alignment, dashes are inserted. The 20 nucleotides belonging to the rbgA coding sequence are underlined