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. 2021 Nov 5;21:1182. doi: 10.1186/s12885-021-08902-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Mutation landscapes of high- and low-risk groups. (A-B) Waterfall plots showing detailed mutation information for the top 20 most commonly mutated genes in CRC patients in the high-risk (A) and low-risk (B) groups. Gene names and mutation frequency are shown in the bar chart on the left. Somatic mutation types are indicated by different colors. The bar plot above the diagram shows the translational effects and numbers of mutations per million bases (MB). (C) Key genes, including TP53, PIK3CA, and MUC16, showed significant differences in mutation frequency between the high- and low-risk groups. (D) The low-risk group had a higher TMB level (P = 0.0002)