Bubnova 2020.

Study characteristics
Methods	Study design: single‐centre RCT (4 arms) Country: Russia Dates participants recruited: NR Maximum follow‐up: 12 months
Participants	Inclusion criteria: patients after AMI ( > 3 weeks) and percutaneous coronary interventions (PCI) at the age of < 60 years for men and < 55 years for women Exclusion criteria: inadequately controlled hypertension, aortic or left ventricular (LV) aneurysm with thrombosis, serious arrhythmias, NYHA class III‐IV HF, BMI ≥ 40 kg/m2, moderate/severe diabetes and other severe comorbidities N randomised: total: 312; intervention 1 (BMI < 30 kg/m2) = 78; intervention 2 (BMI ≥ 30 kg/m2) = 78; comparator 1 (BMI < 30 kg/m2) = 78; comparator 2 (BMI ≥ 30 kg/m2) = 78 Diagnosis (% of participants): 100% post MI with PCI Age (mean ±SD): intervention 1 (BMI < 30 kg/m2) = 51.9±7.9; intervention 2 (BMI ≥ 30 kg/m2) = 51.7±6.8; comparator 1 (BMI < 30 kg/m2) = 52.2±7.2; comparator 2 (BMI ≥ 30 kg/m2) = 52.6±6.7 Percentage male: intervention 1 (BMI < 30 kg/m2) = 93.6%; intervention 2 (BMI ≥ 30 kg/m2) = 96.2%; comparator 1 (BMI < 30 kg/m2) = 94.9%; comparator 2 (BMI ≥ 30 kg/m2) = 93.6% Ethnicity: NR
Interventions	Intervention: physical rehabilitation programme included group exercise classes lasting 60 minutes 3 times/week involving a set of gymnastic exercises of moderate intensity Components: exercise only Setting: centre‐based Exercise programme modality: gymnastic exercises Length of session: 1 hour Frequency: three sessions per week Intensity: 60% of the threshold value according to cycle ergometer test Resistance training included? No Total duration: 1 year Co‐interventions: none described Comparator: control participants did not use exercise training programme Co‐interventions: none described
Outcomes	Mortality, MI, HRQoL
Source of funding	Not reported
Conflicts of interest	None declared
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	“Patients were randomised into four groups depending on BMI”. Authors provided further information: "randomly assigned to the physical training or to the control group using a computer programme".
Allocation concealment (selection bias)	Low risk	Authors provided further information: "The allocation sequence was concealed from enrolling researcher".
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No information provided regarding blinding
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No PRISMA flow diagram or description of attrition
Selective reporting (reporting bias)	Unclear risk	No published protocol available, but outcomes described in methods appear to be reported.