Giallauria 2008.

Study characteristics
Methods	Study design: single‐centre RCT Country: Italy Dates participants recruited: NR Maximum follow‐up: 6 months
Participants	Inclusion criteria: acute ST elevation MI Exclusion criteria: residual myocardial ischaemia, severe ventricular arrhythmias, AV block, valvular disease requiring surgery, pericarditis, severe renal dysfunction (creatinine > 2.5 mg/dL) N randomised: total: 61; intervention: 30; comparator: 31 Diagnosis (% of participants): MI: 100% Age (mean ±SD): intervention: 55.9 ± 3.1; comparator: 55.1 ± 3.7 Percentage male: intervention: 73%; comparator: 71% Ethnicity: NR
Interventions	Intervention: training sessions were supervised under continuous electrocardiography monitoring. Each session was preceded by a 5‐min warm‐up and followed by a 5‐min cool‐down. Exercise was performed for 30 min on a bicycle ergometer with the target of 60% to 70% of VO2 peak achieved at the initial symptom‐limited cardiopulmonary exercise test. Exercise workload was gradually increased until the achievement of the predefined target. Components: exercise only Setting: supervised in centre Exercise programme modality: bicycle ergometer Length of session: 40 min Frequency: 3 times a week Intensity: target of 60% to 70% of VO2 peak achieved at the initial symptom‐limited cardiopulmonary exercise test Resistance training included? No Total duration: 6 months Co‐interventions: none described Comparator: discharged with generic instructions on maintaining physical activity and a correct lifestyle Co‐interventions: none described
Outcomes	Fatal/non‐fatal MI (6 month follow‐up)
Source of funding	"None"
Conflicts of interest	"None"
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"randomized"
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding of outcome assessment (detection bias) All outcomes	Low risk	"The physician performing all Doppler‐echocardioraphy studies was....blinded to the patient allocation into the study protocol."
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants were accounted for.
Selective reporting (reporting bias)	Low risk	All outcomes were reported at all time points.