Maroto 2005.

Study characteristics
Methods	Study design: single‐centre RCT Country: Spain Dates participants recruited: NR (2‐year enrolment period) Maximum follow‐up: 10 years
Participants	Inclusion criteria: male participants diagnosed with AMI and admitted to the coronary care unit; age < 65 years; low risk (hospital course without complications, absence of signs of myocardial ischaemia, functional capacity > 7 metabolic equivalent time (MET), ejection fraction > 50%, and absence of severe ventricular arrhythmias) Exclusion criteria: none described N randomised: total: 180; intervention: 90; comparator: 90 Diagnosis (% of participants): AMI: 100% Anterior: intervention: 40.0%; comparator: 48.3% Inferior/posterior: intervention: 48.3%; comparator: 46.3% Non‐Q wave: intervention: 11.6%; comparator: 5.3% Age (mean ± SD): intervention: 50.3 ± 6; comparator: 52.6 ± 9 Percentage male: 100% Ethnicity: NR
Interventions	Intervention: Multidisciplinary CR programme, consisting of: three months supervised, individualised physical training; psychological programme including behavior modification techniques, group therapy, and relaxation sessions; educational programme on modifying lifestyle and controlling coronary risk factors; return to work counselling. Supervised training was complemented by progressively increasing daily walks of 1 hour in duration, when participants tried to maintain the heart rate achieved during training. Walks were undertaken by participants individually and were unsupervised. Components: exercise plus psychological plus education plus return to work counselling Setting: individualised supervised programme in hospital gym Exercise programme modality: physiotherapy and aerobic training on mats or an exercise bicycle Length of session: 1‐hour sessions Frequency: 3 times per week Intensity: 75% to 85% max HR. Resistance training included? No Total duration: 3 months Co‐interventions: participants received a psychological programme including behaviour modification techniques, group therapy, and relaxation sessions, an educational programme on modifying lifestyle and controlling coronary risk factors, and return to work counselling. Comparator: participants received conventional treatment Co‐interventions: none described
Outcomes	Mortality, MI
Source of funding	NR
Conflicts of interest	NR
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"The 180 patients were randomized into 2 groups”.
Allocation concealment (selection bias)	Unclear risk	Allocation concealment is not described.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Blinding not described
Incomplete outcome data (attrition bias) All outcomes	Low risk	7/90 lost to sample in intervention group and 4/90 lost to sample in control group.
Selective reporting (reporting bias)	Low risk	All outcomes described in methods section are reported at all time points.