Miller 1984.

Study characteristics
Methods	Study design: RCT; participants randomised 3 weeks post‐MI Country: USA Dates participants recruited: NR Maximum follow‐up: 6 months
Participants	Inclusion criteria: men < 70 years with MI documented by the combination of characteristic elevation of serum creatine kinase or oxaloacetic transaminase, a history of prolonged chest pain consistent with myocardial infarction, and the appearance of new Q waves or evolutionary ST segment changes. Exclusion criteria: conditions that precluded symptom‐limited treadmill testing 3 weeks after infarction. e.g. congestive heart failure, unstable angina pectoris, valvular heart disease, atrial fibrillation, bundle branch block, stroke, limiting orthopedic abnormalities, peripheral vascular disease, chronic obstructive pulmonary disease and obesity, a history of coronary artery bypass graft (CABG) surgery, reinfarction before testing, and intercurrent noncardiac illness. N randomised: total: 198; group 1: 66; group 2: 61; group 3: 34; comparator: 37 Diagnosis (% of participants): MI: 100% Age (mean ±SD): 52 ± 9 Percentage male: 100% Ethnicity: NR
Interventions	Participants were randomly assigned to one of four exercise protocols: group 1: 8 to 26 weeks of training at home; group 2: training in a group programme; group 3: treadmill testing at 3 weeks without subsequent training; control: treadmill testing for the first time at 26 weeks. Regimens of home and group exercise training were designed to provide a similar intensity and duration of exercise training. Intervention: home training Components: exercise only Setting: home Exercise programme modality: stationary cycling or walking Length of session: 30 min Frequency: 5 days a week Intensity: weeks 3 to 11: 70% to 85% of the peak heart rate at week 3; weeks 11 to 26: 70% to 85% of the peak heart rate at week 11. Resistance training included? No Total duration: 8 weeks or 26 weeks. Co‐interventions: none described Intervention: group training Components: exercise Setting: supervised in centre Exercise programme modality: walking or jogging Length of session: 1 hour Frequency: 3 times a week Intensity: participants regulated their training intensity by palpation of the radial or carotid pulse during the first 10 sec after brief cessation of walking or jogging. Resistance training included? No Total duration: 8 weeks or 26 weeks Co‐interventions: none described Comparator: usual care (treadmill testing for the first time at 26 weeks) Co‐interventions: none described
Outcomes	CHD mortality, non‐fatal MI and revascularisation
Source of funding	Supported by grant from the NHLBI, Bethesda, and by a grant from the PepsiCo Foundation, Purchase, NY
Conflicts of interest	NR
Notes	Low rate of cardiac events reflects identification of low risk population
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not reported
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Blinding not described
Incomplete outcome data (attrition bias) All outcomes	High risk	5% lost to follow‐up; no description of withdrawals or dropouts
Selective reporting (reporting bias)	Low risk	All outcomes reported for all time points