NCT04511182.

Study name	Early Individualized‐Exercise Based Cardiac Rehabilitation Programs in Patients With Acute Myocardial Infarction
Methods	RCT
Participants	Inclusion criteria: Acute myocardial infarction (AMI) within 1 month prior to recruitment. Complete revascularisation. Men or non‐pregnant women aged from 18 to 80 years. Exclusion criteria: Uncontrolled hypertension (systolic blood pressure/diastolic blood pressure > 160/100 mmHg), or symptomatic hypotension. Significant resting electrocardiogram abnormalities (left bundle branch block, non‐specific intraventricular conduction delay, left ventricular hypertrophy, resting ST‐segment depression), life‐threatening cardiac arrhythmias. Acute myocarditis, pericarditis or acute systemic illness. Those who are assessed by the doctor as high‐risk. Pacemaker or implantable cardioverter defibrillator. Any contraindication to exercise testing or exercise training or inability to complete a CPET. Life‐threatening diseases with limited life expectancy < 3 year. Uncontrolled unstable angina pectoris. Significant valvular disease (mitral stenosis, moderate to severe mitral insufficiency, aortic stenosis, or aortic insufficiency, severe mitral / aortic regurgitation). Severe mental or cognitive impairment. Inability to follow the procedures of the study.
Interventions	Intervention: exercise intervention group. Participants will receive standard medications plus exercise based CR. Education covering topics related to AMI and exercise for AMI will be implemented and any consultations on exercise prescription and disease management will be explained by a cardiac rehabilitation team consisting of cardiologists, cardiology nurses and physiotherapists. Comparator: participants will receive standard medications according to national guidelines, as well as education and consultations as intervention group. However, no exercise prescription is given.
Outcomes	HRQoL (SF‐36), MACE
Starting date	1 February 2021
Contact information	Qin Shao: shaoqindr@126.com
Notes