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. 2021 Oct 21;134(20):jcs258894. doi: 10.1242/jcs.258894

Fig. 1.

Fig. 1.

Surface proteome analysis identifies fatty acid-binding protein 7 as novel sortilin target in neurons but not astrocytes. (A) Workflow of surface proteome analysis in primary neurons from wild-type (WT) and Sort1−/− (KO) mice. (B) Comparison of the surface proteomes of WT and KO primary neurons (n=3 biological replicates/group; two technical replicates per biological replicate). Dashed lines show threshold values for log2 (fold change) and −log10 (P-value), ±0.3 and 1.3, respectively. Proteins with increased (green) or decreased (red) levels in the surface proteome of KO neurons are color-coded. Selected proteins with altered surface exposure in KO neurons are highlighted (see Table S1 for details). (C) Data as in B but comparing the surface proteomes of WT and KO primary astrocytes (n=6 biological replicates/group). Selected proteins with altered surface exposure in KO astrocytes are highlighted (see Table S1 for details).