Table 1.
Demographic and Clinical Characteristics
| Variable | Total (n=8098) | No VF (n=7785) | VF (n=313) | p-value |
|---|---|---|---|---|
| Age (years) | 0.033 | |||
| <30 | 1443(17.8%) | 1402(18%) | 41(13.1%) | |
| 30–50 | 5529(68.3%) | 5311(68.2%) | 218(69.6%) | |
| >50 | 1126(13.9%) | 1072(13.8%) | 54(17.3%) | |
| Gender | 0.082 | |||
| Male | 7635(94.3%) | 7347(94.4%) | 288(92.0%) | |
| Female | 463(5.7%) | 438(5.6%) | 25(8.0%) | |
| HIV transmission route | ||||
| Homosexual | 6264(77.3%) | 6058(77.8%) | 206(65.8%) | <0.001 |
| Heterosexual | 1034(12.8%) | 981(12.6%) | 53(16.9%) | |
| Intravenous drug users | 104(1.3%) | 97(1.2%) | 7(2.3%) | |
| Former plasma donors | 51(0.6%) | 35(0.5%) | 16(5.1%) | |
| Other | 645(8.0%) | 614(7.9%) | 31(9.9%) | |
| Marital | 0.019 | |||
| Unmarried | 5772(71.3%) | 5565(71.5%) | 207(66.1%) | |
| Married | 1887(23.3%) | 1792(23.0%) | 95(30.4%) | |
| Widowed | 396(4.9%) | 386(5.0%) | 10(3.2%) | |
| Divorced | 43(0.5%) | 42(0.5%) | 1(0.3%) | |
| CD4 cell count at baseline(cells/ul) | ||||
| <50 | 969(12.0%) | 900(11.5%) | 69(22.1%) | <0.001 |
| 50–199 | 1719(21.2%) | 1616(20.8%) | 103(32.9%) | |
| 200–349 | 2714(33.5) | 2631(33.8%) | 83(26.5%) | |
| ≥350 | 2696(33.3%) | 2638(33.9%) | 58(18.5%) | |
| HIV-1 RNA at baseline (copies/mL) | <0.001 | |||
| ≤100,000 | 3539(43.7%) | 3438(44.2%) | 101(32.3%) | |
| >100,000 | 1675(20.7%) | 1552(19.9%) | 123(39.3%) | |
| Unknown | 2884(35.6%) | 2795(35.9%) | 89(28.4%) | |
| HBV infection | 0.052 | |||
| Yes | 230(2.8%) | 224(2.9%) | 6(1.9%) | |
| No | 5352(66.1%) | 5161(66.3%) | 191(61.0%) | |
| Unknown | 2516(31.1%) | 2400(30.8%) | 116(37.1%) | |
| HCV infection | 0.019 | |||
| Yes | 139(1.7%) | 136(1.7%) | 3(1%) | |
| No | 4956(61.2%) | 4785(61.5%) | 171(54.6%) | |
| Unknown | 3003(37.1%) | 2864(36.8%) | 139(44.4%) | |
| Initial ART regimen | 0.331 | |||
| 2NRTIs+1NNRTI | 7912(97.7%) | 7609(97.7%) | 303(96.8%) | |
| 2NRTIs+1PI | 186(2.3%) | 176(2.3%) | 10(3.2%) | |
| Blip | 0.886 | |||
| No blip | 7773(96.0%) | 7472(96.0%) | 301(96.2%) | |
| Blip | 325(4.0%) | 313(4.0%) | 12(3.8%) | |
| pLLV | <0.001 | |||
| No pLLV | 7996(98.7%) | 7719(99.2%) | 277(88.5%) | |
| pLLV | 102(1.3%) | 66(0.8%) | 36(11.5%) |
Abbreviations: VF, virological failure; HBV, hepatitis B virus; HCV, hepatitis C virus; NRTI, nucleoside reverse transcriptase inhibitors; NNRTI, non-nucleoside reverse transcriptase inhibitor; PI, protease inhibitor; Blip, intermittent low-level viremia; pLLV, persistent low-level viremia.