Table 4.
Multivariate Cox Analyses of PFS and OS
| A. NLR and STM Multivariate Cox Analysis | PFS | OS | |||
| HR (95% CI) | P | HR (95% CI) | P | ||
| Radiotherapy | Yes vs No | 1.079 (0.432–2.691) | 0.871 | 0.843 (0.342–2.078) | 0.710 |
| Mono-immunotherapy | Yes vs No | 1.786 (0.758–4.212) | 0.185 | / | / |
| Leading STM change | Decrease <20% vs Decrease ≥20% | 2.892 (0.976–8.568) | 0.055 | 0.510 (0.193–1.350) | 0.175 |
| Pretreatment NLR | ≥5 vs <5 | / | / | 0.805 (0.308–2.099) | 0.657 |
| Posttreatment NLR | ≥5 vs <5 | 0.144 (0.048–0.427) | 0.001 | 0.122 (0.042–0.352) | 0.001 |
| B. The Combination Score Multivariate Cox Analysis | PFS | OS | |||
| HR (95% CI) | P | HR (95% CI) | P | ||
| Radiotherapy | Yes vs No | 1.049 (0.417–2.643) | 0.919 | 0.807 (0.329–1.976) | 0.630 |
| Mono-immunotherapy | Yes vs No | 1.860 (0.772–4.480) | 0.167 | / | / |
| Combination Score | 0 | ||||
| 1 | 3.661 (1.136–11.792) | 0.030 | 3.183 (1.02–9.931) | 0.046 | |
| 2 | 20.066 (5.646–71.311) | <0.0001 | 22.299 (6.381–77.924) | <0.0001 | |
Notes: Cox regression models were applied to find independent indicators associated with PFS and OS and estimate the hazard ratio (HR). Factors which were statistically significant in the univariate analysis were incorporated into the multivariate analysis. Figures are given as HR (95% CI). A P value of < 0.05 was regarded statistically significant.
Abbreviations: PFS, progression-free survival; OS, overall survival; HR: hazard ratio; CI, confidence interval.