Table 2.

Clinical Trials Regarding Anti-Inflammatory Effects of Curcumin in Treatment of Diseases

Curcumin	Disease	Dose(s)	Duration	Outcome(s)	Ref
Curcumin	Metabolic syndrome	1 g daily	8 weeks	↓ TNF-α, IL-6, TGF-β and MCP-1	[23]
Curcumin nanomicelle	Male factor infertility	80 mg daily	10 weeks	↓ CRP, TNF-α	[24]
Sinacurcumin®	Osteoarthritis	80 mg daily	3 mouths	↓ Visual Analog Score (VAS), CRP, CD4+ and CD8+ T cells, Th17 cells and B cells frequency	[25]
Theracurmin®	Crohn’s disease	360 mg daily	12 weeks	Significant clinical and endoscopic efficacy together with a favorable safety profile.	[40]
IQP-CL-101(Each IQP-CL-101 softgel contains 330 mg proprietary mixture of curcuminoids and essential oils.)	Irritable Bowel Syndrome	Two softgels daily	8 weeks	Beneficial in the improvement of IBS symptom severity, improve quality of life in patients suffering from abdominal pain and discomfort.	[52]
Curcuma longa extract	Knee osteoarthritis	CL extract 500 mg along with Diclofenac twice a day	4 months	Suppresses inflammation and brings clinical improvement in patients of KOA, which may be observed by decreased level of IL-1β and VAS/WOMAC scores, respectively.	[71]
Curcuma longa extract	Knee osteoarthritis and knee effusion-synovitis	2 capsules of CL, daily	12 weeks	CL was more effective than placebo for knee pain but did not affect knee effusion–synovitis or cartilage composition.	[72]
Herbal formulation “turmeric extract, black pepper, and ginger”	Knee osteoarthritis	Curcumin (300 mg), twice a day	4 weeks	↓ PGE2	[73]
Curcumin	Rheumatoid arthritis	500mg, twice daily oral	8 weeks	Improvement in overall DAS and ACR scores.	[74]
Curcuminoid C3 Complex	Psoriasis	4.5g,	12 weeks	The response rate was low and possibly due to a placebo effect or the natural history of psoriasis.	[89]
Curcumin	Major Depression	500–1500 mg/day	12 weeks	Significant antidepressant effects.	[113]
SinaCurcumin	COVID-19	40 mg, twice daily	2 weeks	Significantly improve recovery time.	[139]
Curcumin with Piperine	COVID-19	Curcumin (525 mg) with piperine (2.5mg) in tablet form twice a day.	14 days	Substantially reduce morbidity and mortality, and ease the logistical and supply-related burdens on the healthcare system.	[140]
Theracurmin®	Knee osteoarthritis	6 capsules of Theracurmin per day	6 months	shows great potential for the treatment of human knee osteoarthritis.	[169]
Curcumagalactomannoside complex (CurQfen)	Knee osteoarthritis	400 mg, daily	6 weeks	exerted beneficial effects in alleviating the pain and symptoms.	[170]
CuraMed® Curamin®	Osteoarthritis	500-mg capsules (333 mg curcuminoids) 500-mg capsules (350 mg curcuminoids and 150 mg boswellic acid) taken orally three times a day	12 weeks	Reduces pain-related symptoms in patients with OA.	[183]
LI73014F2	Knee osteoarthritis	200, 400 mg/day	90 days	Significant pain relief, improved physical function, and quality of life in OA patients.	[184]