Summary of findings for the main comparison. Cells compared to no cells for acute myocardial infarction (AMI).
| Cells compared to no cells for acute myocardial infarction (AMI) | ||||||
| Patient or population: patients with AMI Settings: Hospitalised patients Intervention: cells Comparison: no cells | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| No cells | Cells | |||||
| All‐cause mortality ‐ short‐term follow‐up (< 12 months) | Study population | RR 0.80 (0.43 to 1.49) | 1365 (17 RCTs) | ⊕⊕⊕⊝ MODERATE 1 | Further research may change the estimate | |
| 28 per 1000 | 23 per 1000 (12 to 42) | |||||
| All‐cause mortality ‐ long‐term follow‐up (≥ 12 months) | Study population | RR 0.93 (0.58 to 1.50) | 996 (14 RCTs) | ⊕⊕⊕⊝ MODERATE 1 | Further research may change the estimate | |
| 70 per 1000 | 65 per 1000 (41 to 105) | |||||
| Cardiovascular mortality ‐ short‐term follow‐up (< 12 months) | Study population | RR 0.72 (0.28 to 1.82) | 290 (7 RCTs) | ⊕⊕⊕⊝ MODERATE 1 | Further research may change the estimate | |
| 54 per 1000 | 39 per 1000 (15 to 99) | |||||
| Cardiovascular mortality ‐ long‐term follow‐up (≥ 12 months) | Study population | RR 1.04 (0.54 to 1.99) | 527 (9 RCTs) | ⊕⊕⊕⊝ MODERATE 1 | Further research may change the estimate | |
| 72 per 1000 | 75 per 1000 (39 to 143) | |||||
| Composite death, reinfarction and hospitalisation for heart failure ‐ short‐term follow‐up (< 12 months) | Study population | RR 0.36 (0.12 to 1.14) | 379 (3 RCTs) | ⊕⊕⊕⊝ MODERATE 1 | Further research may change the estimate | |
| 66 per 1000 | 24 per 1000 (8 to 76) | |||||
| Composite death, reinfarction and hospitalisation for heart failure ‐ long‐term follow‐up (≥ 12 months) | Study population | RR 0.63 (0.36 to 1.10) | 497 (6 RCTs) | ⊕⊕⊕⊝ MODERATE 1 | Further research may change the estimate | |
| 140 per 1000 | 88 per 1000 (51 to 154) | |||||
| *The assumed risk is based on the observed incidence across the pooled control groups. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; RCT: randomised controlled trial; RR: risk ratio | ||||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1Imprecision: information size criterion not met. Small size effect.