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. 2015 Sep 30;2015(9):CD006536. doi: 10.1002/14651858.CD006536.pub4

Comparison 1. Cells compared to no cells.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 All‐cause mortality 23   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
1.1 Short‐term follow‐up (< 12 months) 17 1365 Risk Ratio (M‐H, Random, 95% CI) 0.80 [0.43, 1.49]
1.2 Long‐term follow‐up (≥ 12 months) 14 996 Risk Ratio (M‐H, Random, 95% CI) 0.93 [0.58, 1.50]
2 Cardiovascular mortality 10   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
2.1 Short‐term follow‐up (< 12 months) 7 290 Risk Ratio (M‐H, Random, 95% CI) 0.72 [0.28, 1.82]
2.2 Long‐term follow‐up (≥ 12 months) 9 527 Risk Ratio (M‐H, Random, 95% CI) 1.04 [0.54, 1.99]
3 Composite measure of death, reinfarction, re‐hospitalisation for heart failure 6   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
3.1 Short‐term follow‐up (< 12 months) 3 379 Risk Ratio (M‐H, Random, 95% CI) 0.36 [0.12, 1.14]
3.2 Long‐term follow‐up (≥ 12 months) 6 497 Risk Ratio (M‐H, Random, 95% CI) 0.63 [0.36, 1.10]
4 Incidence of reinfarction 20   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
4.1 Short‐term follow‐up (< 12 months) 17 1521 Risk Ratio (M‐H, Random, 95% CI) 0.66 [0.33, 1.30]
4.2 Long‐term follow‐up (≥ 12 months) 14 1116 Risk Ratio (M‐H, Random, 95% CI) 0.64 [0.36, 1.12]
5 Incidence of re‐hospitalisation for heart failure 16   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
5.1 Short‐term follow‐up (< 12 months) 13 1194 Risk Ratio (M‐H, Random, 95% CI) 0.81 [0.40, 1.62]
5.2 Long‐term follow‐up (≥ 12 months) 10 825 Risk Ratio (M‐H, Random, 95% CI) 0.55 [0.30, 1.00]
6 Incidence of target vessel revascularisation 11   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
6.1 Short‐term follow‐up (< 12 months) 6 789 Risk Ratio (M‐H, Random, 95% CI) 0.70 [0.47, 1.06]
6.2 Long‐term follow‐up (≥ 12 months) 8 758 Risk Ratio (M‐H, Random, 95% CI) 0.96 [0.67, 1.37]
7 Incidence of arrhythmias 8   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
7.1 Short‐term follow‐up (< 12 months) 5 525 Risk Ratio (M‐H, Random, 95% CI) 1.00 [0.51, 1.98]
7.2 Long‐term follow‐up (≥ 12 months) 5 457 Risk Ratio (M‐H, Random, 95% CI) 1.39 [0.58, 3.37]
8 Incidence of restenosis 13   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
8.1 Short‐term follow‐up (< 12 months) 8 641 Risk Ratio (M‐H, Random, 95% CI) 0.95 [0.63, 1.43]
8.2 Long‐term follow‐up (≥ 12 months) 6 395 Risk Ratio (M‐H, Random, 95% CI) 0.58 [0.27, 1.25]
9 Quality of life measures 3   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
9.1 Short‐term follow‐up (< 12 months) 3 154 Std. Mean Difference (IV, Random, 95% CI) 0.58 [‐0.67, 1.83]
9.2 Long‐term follow‐up (≥ 12 months) 1 26 Std. Mean Difference (IV, Random, 95% CI) 3.23 [2.01, 4.46]
10 NYHA classification 7   Mean Difference (IV, Random, 95% CI) Subtotals only
10.1 Short‐term follow‐up (< 12 months) 5 398 Mean Difference (IV, Random, 95% CI) ‐0.07 [‐0.24, 0.09]
10.2 Long‐term follow‐up (≥ 12 months) 4 237 Mean Difference (IV, Random, 95% CI) ‐0.23 [‐0.53, 0.07]
11 Exercise tolerance 5   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
11.1 Short‐term follow‐up (< 12 months) 5 267 Std. Mean Difference (IV, Random, 95% CI) 0.19 [‐0.06, 0.43]
11.2 Long‐term follow‐up (≥ 12 months) 1 45 Std. Mean Difference (IV, Random, 95% CI) ‐0.05 [‐0.68, 0.58]
12 Maximum VO2 (mL/kg/min) 3   Mean Difference (IV, Random, 95% CI) Subtotals only
12.1 Short‐term follow‐up (< 12 months) 3 175 Mean Difference (IV, Random, 95% CI) 1.15 [‐0.77, 3.07]
12.2 Long‐term follow‐up (≥ 12 months) 1 45 Mean Difference (IV, Random, 95% CI) 0.40 [‐3.76, 4.56]
13 VE/VCO2 slope 3   Mean Difference (IV, Random, 95% CI) Subtotals only
13.1 Short‐term follow‐up (< 12 months) 3 174 Mean Difference (IV, Random, 95% CI) 0.28 [‐1.02, 1.57]
13.2 Long‐term follow‐up (≥ 12 months) 1 45 Mean Difference (IV, Random, 95% CI) 0.0 [‐3.07, 3.07]
14 Peak heart rate (bpm) 3   Mean Difference (IV, Random, 95% CI) Subtotals only
14.1 Short‐term follow‐up (< 12 months) 3 198 Mean Difference (IV, Random, 95% CI) 0.55 [‐6.79, 7.89]
14.2 Long‐term follow‐up (≥ 12 months) 1 45 Mean Difference (IV, Random, 95% CI) ‐9.10 [‐20.59, 2.39]
15 LVEF measured by MRI (<12 months) 15   Mean Difference (IV, Random, 95% CI) Subtotals only
15.1 Mean change from baseline 13 1057 Mean Difference (IV, Random, 95% CI) 0.43 [‐1.16, 2.03]
15.2 Mean value at endpoint 15 1125 Mean Difference (IV, Random, 95% CI) 0.81 [‐0.78, 2.41]
15.3 Combined 15 1135 Mean Difference (IV, Random, 95% CI) 1.05 [‐0.56, 2.67]
16 LVEF measured by MRI (≥ 12 months) 9   Mean Difference (IV, Random, 95% CI) Subtotals only
16.1 Mean change from baseline 5 438 Mean Difference (IV, Random, 95% CI) 0.03 [‐1.72, 1.78]
16.2 Mean value at endpoint 8 551 Mean Difference (IV, Random, 95% CI) 1.40 [‐1.54, 4.34]
16.3 Combined 9 718 Mean Difference (IV, Random, 95% CI) 1.27 [‐1.14, 3.68]
17 LVEF measured by echocardiography (< 12 months) 20   Mean Difference (IV, Random, 95% CI) Subtotals only
17.1 Mean change from baseline 6 372 Mean Difference (IV, Random, 95% CI) 2.72 [1.50, 3.95]
17.2 Mean value at endpoint 20 862 Mean Difference (IV, Random, 95% CI) 2.15 [0.89, 3.42]
17.3 Combined 20 862 Mean Difference (IV, Random, 95% CI) 2.31 [1.30, 3.33]
18 LVEF measured by echocardiography (≥12 months) 10   Mean Difference (IV, Random, 95% CI) Subtotals only
18.1 Mean change from baseline 3 127 Mean Difference (IV, Random, 95% CI) 1.35 [‐2.25, 4.96]
18.2 Mean value at endpoint 9 377 Mean Difference (IV, Random, 95% CI) 2.87 [1.42, 4.31]
18.3 Combined 10 433 Mean Difference (IV, Random, 95% CI) 2.09 [0.74, 3.44]
19 LVEF measured by SPECT (< 12 months) 7   Mean Difference (IV, Random, 95% CI) Subtotals only
19.1 Mean change from baseline 5 286 Mean Difference (IV, Random, 95% CI) 2.72 [0.23, 5.21]
19.2 Mean value at endpoint 6 375 Mean Difference (IV, Random, 95% CI) 2.19 [0.58, 3.81]
19.3 Combined 7 394 Mean Difference (IV, Random, 95% CI) 2.52 [0.59, 4.44]
20 LVEF measured by SPECT (≥ 12 months) 4   Mean Difference (IV, Random, 95% CI) Subtotals only
20.1 Mean change from baseline 2 92 Mean Difference (IV, Random, 95% CI) 5.63 [1.77, 9.49]
20.2 Mean value at endpoint 3 181 Mean Difference (IV, Random, 95% CI) 3.46 [0.82, 6.11]
20.3 Combined 4 200 Mean Difference (IV, Random, 95% CI) 4.42 [2.68, 6.16]
21 LVEF measured by left ventricular angiography (< 12 months) 9   Mean Difference (IV, Random, 95% CI) Subtotals only
21.1 Mean change from baseline 3 279 Mean Difference (IV, Random, 95% CI) 6.43 [0.60, 12.27]
21.2 Mean value at endpoint 9 711 Mean Difference (IV, Random, 95% CI) 4.94 [0.53, 9.35]
21.3 Combined 9 711 Mean Difference (IV, Random, 95% CI) 5.09 [0.95, 9.24]
22 LVEF measured by left ventricular angiography (≥ 12 months) 1   Mean Difference (IV, Random, 95% CI) Subtotals only
22.1 Mean value at endpoint 1 62 Mean Difference (IV, Random, 95% CI) 8.0 [4.27, 11.73]
23 LVEF measured by radionuclide ventriculography (RNV) (<12 months) 3   Mean Difference (IV, Random, 95% CI) Subtotals only
23.1 Mean change from baseline 2 118 Mean Difference (IV, Random, 95% CI) 0.91 [‐3.11, 4.94]
23.2 Mean value at endpoint 3 157 Mean Difference (IV, Random, 95% CI) 1.08 [‐4.88, 7.04]
23.3 Combined 3 157 Mean Difference (IV, Random, 95% CI) 1.79 [‐1.86, 5.43]
24 LVEF measured by radionuclide ventriculography (≥ 12 months) 1   Mean Difference (IV, Random, 95% CI) Subtotals only
24.1 Mean value at endpoint 1 39 Mean Difference (IV, Random, 95% CI) 6.30 [‐1.03, 13.63]