Silva 2014.
| Methods |
Type of study: parallel RCT Type of publication: abstract Source of funding: not reported Country of origin: Portugal Number of centres: 1 Dates of trial enrolment: 01/2011 to 05/2013 Length of follow‐up: 12 months Number (N) of participants randomised to each arm: not reported Number (N) of participants analysed (primary outcome) in each arm: not reported |
| Participants |
Population: patients with AMI. BMSC transplantation after successful PCI. PCI within 12 hours of AMI
Age mean (SD) each arm: 50.9 (9.5) years
Sex % male in each arm: 91% male Number of diseased vessels: not reported Number of stunned hyperkinetic, etc segments: not reported Time from symptom onset to initial treatment: < 12 hours Statistically significant baseline imbalances between the groups? not reported |
| Interventions |
Intervention arm: bone marrow progenitor cells
Type of stem cells: bone marrow progenitor cells
Summary of how stem cells were isolated and type and route of delivery: not reported, except for intracoronary delivery of the cells Dose of stem cells: not reported Timing of stem cell procedure: 7 days after AMI Comparator arm: no additional therapy (control) |
| Outcomes | Primary outcomes: changes in global longitudinal strain (GLS) and LVEF Secondary outcomes: not reported Outcome assessment points: baseline, 6 months and 12 months Method(s): echocardiography |
| Notes | — |
18F‐FDG, fluorodeoxyglucose; AMI, acute myocardial infarction; BMMNC, bone marrow‐derived mononuclear cells; BMSC, bone marrow stem/progenitor cell; BNP, brain natriuretic peptide; cMRI, cardiac magnetic resonance imaging; DES, drug‐eluting stent; G‐CSF, granulocyte colony stimulating factor; HF, heart failure; LVEDV, left ventricular end diastolic volume; LVEF, left ventricular ejection fraction; LVESV, left ventricular end systolic volume; MACE, major adverse cardiac events; MBF, myocardial blood flow; MHFQ, Minnesota Heart Failure Questionnaire; MNC, mononuclear cell; NT‐proBNP, N‐terminal prohormone of brain natriuretic peptide; NYHA, New York Heart Association; PET, positron emission tomography; RCT, randomised controlled trial; SPECT, single photon emission computed tomography