NCT01394432.

Trial name or title	Endocardial mesenchymal stem cells implantation in patients after acute myocardial infarction (ESTIMATION Study)
Methods	Type of study: parallel RCT Source of funding: not reported Country of origin: Russia Number of centres: not reported Intended enrolment: 50
Participants	Population: AMI with successful PCI Age, mean (SD) each arm: not reported (30 to 75 years) Sex, % male in each arm: not reported Number of diseased vessels: 1 Number of stunned hyperkinetic, etc segments: not reported Time from symptom onset to initial treatment: not reported Statistically significant baseline imbalances between the groups?: not reported
Interventions	Intervention arm: BM‐MSC Type of stem cells: bone marrow‐derived mesenchymal stem cells Summary of how stem cells were isolated and type and route of delivery: not reported, except for delivery using NOGA mapping Dose of stem cells: not reported Timing of stem cell procedure: 7 to 10 days after PCI Comparator arm: placebo
Outcomes	Primary outcomes: reduction of LVESV by 15% Secondary outcomes: death, Thrombosis, hospitalisation for HF, 6 min‐walk, BNP levels Outcome assessment points: baseline, 12 months Method(s): MRI
Starting date	July 2011
Contact information	Principal Investigator: Professor Evgeny Pokushalov, MD; State Research Institute of Circulation Pathology, Novosibirsk, Russian Federation, 630055
Notes	Estimated completion date: November 2012