Table 3.
Guidelines for diagnosis of GDM proposed during the COVID-19 pandemic. OGTT = Oral Glucose Tolerance Test; FPG = fasting plasma glucose; HbA1c = glycated haemoglobin; LGA = large-for-gestational-age; GDM = gestational diabetes mellitus; US = ultrasound; RPG = random plasma glucose; T2DM = Type 2 diabetes mellitus.
Gestation | Screening details | Guidelines, by nation | ||||
---|---|---|---|---|---|---|
Australia [36,37] | Canada [38] | Japan [25] | France [39] | UK[40] | ||
12 weeks | Screening strategy | Risk factor screening = HbA1c in first trimester | Pregnant people at risk of overt diabetes = HbA1c or FPG | Risk factor screening = FPG | At booking for high-risk: HbA1c and RPG | |
Thresholds for diagnosis | HbA1c >5.9% (41 mmol/mol) | HbA1c ≥6.5% (48 mmol/mol) or FPG ≥7.0 mmol/L [41] |
GDM = FPG 5.1–6.9 mmol/L T2DM = FPG ≥7.0 mmol/L |
GDM = HbA1c 5.9–6.5% (41–48 mmol/mol) or RPG 9–11 mmol/L T2DM = HbA1c ≥ 6.5% (48 mmol/mol) or RPG >11.1 mmol/l |
||
28 weeks | Screening strategy | Universal OGTT or FPG | Universal Standard protocol or HbA1c or RPG | Universal HbA1c or RPG or FPG | Selective Standard protocol or HbA1c or FPG | Selective HbA1c or RPG or FPG |
Thresholds for diagnosis of GDM | Standard OGTT thresholds Or Not GDM = FPG ≤4.6 mmol/L Refer OGTT = FPG 4.7–5.0 mmol/L GDM = ≥5.1 mmol/L | Standard = 50 g GCT, if 7.8–11.0 mmol/L then 75 g OGTT Or HbA1c ≥5.7% (39 mmol/mol) or RPG ≥11.1 mmol/l | HbA1c ≥5.7% (39 mmol/mol) Or RPG ≥ 9.0 mmol/L Or FPG ≥ 5.1 mmol/L | HbA1c ≥5.7% (39 mmol/mol) Or FPG ≥5.1 mmol/L | HbA1c ≥5.7% (39 mmol/mol) Or RPG ≥9.0 mmol/L Or FPG ≥5.6 mmol/L If resources allow: FPG ≥5.3 mmol/L | |
Recommendations for other testing | Macrosomia or hydramnios = FPG and HbA1c and/or self-monitoring of blood glucose | Heavy glycosuria, high clinical suspicion of diabetes, LGA or polyhydramnios on US tested for GDM at any pregnancy stage |