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. 2021 Nov 2;16:7369–7371. doi: 10.2147/IJN.S344189

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Histology of the grafted cells in the injection site.

Notes: Fluorescence immunostaining micrographs show that GFP-MSCs remained in the injection site in animals grafted with polymersome-labeled GFP-MSCs and unlabeled GFP-MSCs. Only a few surviving GFP-MSCs differentiated into GFAP-positive astrocytes (arrows), but not into NeuN-positive neurons. A large number of cells were phagocytized by macrophages (arrows) (A). Graphs show the numbers of GFAP⁺GFP⁺ (B), CD11b⁺GFP⁺ (C), and the percentage of GFP-MSCs (D) in animals grafted with polymersome-labeled GFP-MSCs and unlabeled GFP-MSCs. Bar =15 μm.

Abbreviation: MSC, mesenchymal stem cell.