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. 2021 Nov 2;16:7369–7371. doi: 10.2147/IJN.S344189

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Histology of migrating cells in the corpus callosum.

Notes: Fluorescence immunostaining micrographs show that a small amount of GFP-MSCs migrated to the corpus callosum in animals treated with polymersome-labeled cells and unlabeled cells. Only a few surviving GFP-MSCs were differentiated into GFAP-positive astrocytes (arrows) and were phagocytized by macrophages (arrows), but no cells differentiated into NeuN-positive neurons (A). Graphs show the numbers of GFAP⁺GFP⁺ (B), CD11b⁺GFP⁺ (C), and GFP-MSCs (D) in animals grafted with polymersome-labeled GFP-MSCs and unlabeled GFP-MSCs. Bar =15 μm.

Abbreviation: MSC, mesenchymal stem cell.