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. 2021 Nov 7;81(18):2117–2131. doi: 10.1007/s40265-021-01635-6
Pseudomonas aeruginosa is an important Gram-negative organism that is implicated in nosocomial infections, and in patients with structural lung disease, such as in cystic fibrosis.
P. aeruginosa attacks respiratory epithelial cells via its pili and flagellum, and utilizes biofilm formation, quorum sensing, and a type III secretion system to increase its virulence.
Newer antimicrobials that have activity against MDR P. aeruginosa have been shown to be efficacious in the treatment of MDR Pseudomonas.