Pseudomonas aeruginosa is an important Gram-negative organism that is implicated in nosocomial infections, and in patients with structural lung disease, such as in cystic fibrosis. |
P. aeruginosa attacks respiratory epithelial cells via its pili and flagellum, and utilizes biofilm formation, quorum sensing, and a type III secretion system to increase its virulence. |
Newer antimicrobials that have activity against MDR P. aeruginosa have been shown to be efficacious in the treatment of MDR Pseudomonas. |