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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Eur J Nutr. 2021 May 15;60(8):4207–4218. doi: 10.1007/s00394-021-02577-1

Table 4.

Variables selected for predicting dietary protein intake (E%) with their R2 and corresponding cross-validated R2 (%) using serum + 24-hour urine metabolites without participant characteristics or established diet-related biomarkers (Model 1).

Variable# Coefficient R2 CV-R2
Intercept −2.836
Propanediol (urine) −0.082 17.6% 10.1%
Lysophosphatidylethanolamine (LPE 16:0*) (serum) 0.251 17.1% 9.8%
Urea (urine) 0.138 5.7% 3.3%
Arabitol/Xylitol (serum) −0.101 5.3% 3.1%
Creatine (serum) 0.065 4.8% 2.8%
2-Oxoisovalerate (serum) 0.125 4.2% 2.4%
2-Hydroxyglutarate (serum) −0.136 3.4% 1.9%
Maltose (urine) −0.019 1.7% 1.0%
Methyl-glycocholate (urine) −0.046 1.4% 0.8%
2-Hydroxybutyrate (serum) 0.057 0.8% 0.5%
Cholesteryl ester (CE 18:3*) (serum) −0.075 0.6% 0.4%
Glutamine (serum) −0.111 0.3% 0.2%
Uridine (serum) 0.052 0.2% 0.1%
Cholesteryl ester (CE 22:6*) (serum) 0.020 0.1% 0.0%
Creatine (urine) −0.001 0.0% 0.0%
Total 63.2% 36.3%
#

Reordered by R2

*

In LPE 16:0, 16 indicates number of carbons and 0 indicates number of double bonds in the fatty acid chain.

LPE: lysophosphatidylethanolamine. CE: cholesterol ester.