Table 1.

Characteristics of available meta-analyses on the relationship between subclinical hypothyroidism and cardiovascular (CV) morbidity and mortality. MACE = major cardiovascular events

Inclusion criteria	Rodondi et al. [17] (11)	Haentjens et al. [18] (12)	Ochs et al. [19] (13)	Razvi et al. [5] (14)	Singh et al. [21] (15)	Rodondi et al. [22] (16)	Gencer et al. [23] (17)	Ning etal. [11] (9)	Sun et al. [24] (18)	Moon et al. [25] (19)	Du Puy et al. [28] (25)
N. of included studies	14	9	12	15	6	11	6	37	16	35	4
N. of analyzed patients	13,011	14,912	14,449	29,022	14,386	55,287	25,390	1,473,648	71,808	555,530	2,116
Age mean/range (years)	18–95	–	18–95	60	17–89	19–94	21–100	45–83	45.4–85	41–83.4	80–109
Follow Up mean/range (years)	–	2–20	2–20	4–20	4–20	2.5–20	2–16.3	2.5–20	3.2–20	–	5
TSH cut off mU/L Subclinical hypothyroidism	2.8–6.0	4–5.10	4–6	3.7–8.9	4–5	0.50	4.5–19.9	3.1–6.0	4–6	–	4.8

	Yes	No	Yes	No	Yes	No	Yes	No	Yes	No	Yes	No	Yes	No	Yes	No	Yes	No	Yes	No	Yes	No
Unadjusted risk	X		X		X			X		X	X			X	X		X			X		X
Adjusted risk	X			X	X		X		X		X		X			X	X		X		X
Age stratified risk		X		X	X		X			X	X		X		X		X		X		X
TSH stratified risk		X		X	X			X		X	X		X			X		X		X		X
CV events analyzed
MACE		X		X		X		X		X		X		X	X			X	X			X
Coronary events	X			X	X		X		X		X			X	X		X			X		X
Atrial fibrillation		X		X		X		X		X		X		X		X	X			X		X
Heart failure		X		X		X		X		X		X	X			X	X			X		X
CV mortality		X		X	X			X	X		X			X	X		X			X		X
Overall mortality		X	X		X		X		X		X			X	X		X		X		X