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. 2021 Jun 3;60(8):4439–4452. doi: 10.1007/s00394-021-02583-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a–k Effects of PPPH (0.0195–2.5 mg/mL) on insulin release from clonal pancreatic BRIN-BD11 beta-cells at elevated, 16.7 mM, glucose concentration. k Additionally, effects of a fixed (2.5 mg/ml) concentration of various protein hydrolysate on cell viability were also investigated (K). Values are mean ± SEM (n = 8). **p < 0.01, ***p < 0.001 compared to control 16.7 mM glucose (a–k). Con: aqueous/alkaline control, AF: Alcalase/Flavourzyme, Alc: Alcalase, Brom: Bromelain, Prom: Promod