Skip to main content
. 2021 Nov 6;7:337. doi: 10.1038/s41420-021-00729-0

Fig. 6. HMGB1+ EVs activate NLRP3 inflammasomes inducing hepatocyte pyroptosis.

Fig. 6

a, c The primary hepatocytes were isolated from WT and NLRP3−/− mice, the percentage of pyroptotic primary hepatocytes from WT and NLRP3−/− mice were measured by flow cytometry. b, d The level of LDH was examined in wild-type and NLRP3−/− primary hepatocytes when treated with different EVs. (*) P < 0.05 versus control medium; (&) P < 0.05 versus control LPS-EVs; (#) P < 0.05 versus LPS-EVs. e The activation of the NLRP3 inflammasome was analyzed in wild-type and NLRP3−/− primary hepatocytes when treated with different EVs. Data are expressed as means ± sd. *for p < 0.05 vs control group. **for p < 0.01; ## for p < 0.01.