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. 2021 Nov 6;7:337. doi: 10.1038/s41420-021-00729-0

Fig. 7. HMGB1+ EVs cause liver damage and activate NLRP3 inflammasomes in the liver.

Fig. 7

a EVs were collected from Raw264.7 (control, HMGB1-Overexpressing and HMGB1-Knockdown) were injected into WT and NLRP3−/−mice. The LPS or CLP surgery models served as the sepsis positive models. Expression of NLRP3, ASC and Caspase-1 was evaluated; scale bar = 100 μm. n = 5 mice per group. b The expression levels of NLRP3/ASC/Caspase-1 were analyzed by immunoblotting. Data are expressed as means ± sd. * for p < 0.01 vs control group. # for p < 0.05; & for p < 0.05. c–f Serum ALT, AST, LDH and MPO levels. Data are expressed as means ± sd. * for p < 0.01. & for p < 0.05; # for p < 0.01. n = 5 mice per group.