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. 2021 Nov 6;7:337. doi: 10.1038/s41420-021-00729-0

Fig. 8. Serum-derived EVs of patients with sepsis express high HMGB1 and cause liver injury in vivo.

Fig. 8

a HE and IHC staining of MPO, F4/80, NLRP3, ASC, and Caspase-1 in all groups. n = 5 mice per group. b The NLRP3 inflammasome was detected by immunoblotting. c–f The ALT, AST, LDH, and MPO levels. (*) P < 0.05 versus control group. (&) P < 0.05 versus control group; (#) P < 0.05 versus control group; (**) P < 0.01 versus control group. (&&) P < 0.01 versus control group; (##) P < 0.01 versus control group. n = 5 mice per group.