Psoriatic arthritis (PsA) is a complex disease characterized by inflammation of multiple clinical domains, including peripheral joints, skin and nails, axial joints, entheses, eyes, and digits

The similarities in clinical presentation of PsA and other rheumatic diseases such as rheumatoid arthritis (RA) or osteoarthritis (OA) can make a differential diagnosis challenging; therefore, it is crucial for primary care providers, including advanced practice providers (APPs), to be aware of characteristics and criteria indicative of a diagnosis of PsA

Characteristic features can be used to differentiate PsA from RA and OA, and early assessment, diagnosis, and treat-to-target strategies are key to the management of patients with PsA to facilitate the administration of appropriate therapy in a timely manner

Collaboration and coordinated care are key among primary care providers, APPs, and subspecialists to ensure positive outcomes for patients, controlling symptoms and disease activity, maintaining functional ability, and improving patient quality of life