Table 3.
Impact of sex on ASAS40, ASDAS-CRP ID, and BASDAI at week 52
| Predictor | Variables | |||||
|---|---|---|---|---|---|---|
| ASAS40a | ASDAS-CRP IDa | BASDAIb | ||||
| Odds ratio (95% CI) | P value | Odds ratio (95% CI) | P value | Treatment effect (95% CI) | P value | |
| Baseline ASDAS-CRP | NA | NA | 0.66 (0.56, 0.79) | < 0.0001 | NA | NA |
| Baseline BASDAI | NA | NA | NA | NA | 0.54 (0.45, 0.63) | < 0.0001 |
| Sex (male vs. female) | 1.3 (1.0, 1.6) | 0.0992 | 1.7 (1.2, 2.4) | 0.0019 | − 0.1 (− 0.4, 0.2) | 0.4824 |
| Age (years) | 0.98 (0.97, 0.99) | 0.0022 | – | – | 0.02 (0.01, 0.03) | 0.0004 |
| BMI (< 30 kg/m2 vs. ≥ 30 kg/m2) | 1.4 (1.0, 1.8) | 0.0349 | 3.0 (1.9, 4.8) | < 0.0001 | − 0.4 (− 0.8, − 0.1) | 0.0054 |
| TNFi status (naïve vs. IR) | 1.6 (1.2, 2.0) | 0.0006 | 1.9 (1.3, 2.8) | 0.0004 | − 0.4 (− 0.7, − 0.2) | 0.0024 |
| hsCRP (≥ 5 mg/L vs. < 5 mg/L) | 1.7 (1.3, 2.1) | < 0.0001 | – | – | − 0.5 (− 0.8, − 0.2) | 0.0002 |
| Current smoker (no vs. yes) | 1.3 (1.0, 1.7) | 0.0240 | – | – | − 0.3 (− 0.5, 0.0) | 0.0416 |
| BASMI—occiput- to-wall distance (cm) | 0.96 (0.93, 0.98) | 0.0002 | 0.90 (0.87, 0.94) | < 0.0001 | 0.10 (0.05, 0.14) | < 0.0001 |
| BASMI—Tragus to wall distance (cm) | – | – | – | – | − 0.06 (− 0.11, − 0.01) | 0.0198 |
In the final models, except treatment and sex (which were included mandatorily), only those factors with P values < 0.05 were kept
ASAS Assessment of SpondyloArthritis international Society, ASDAS Ankylosing Spondylitis Disease Activity Score, BMI Body Mass Index, CI confidence interval, hs-CRP high sensitivity C-reactive protein, IR inadequate responders, NA not applicable, – not selected in the final model, TNFi tumor necrosis factor inhibitor
aAnalyses were done using multivariate logistic regression
bAnalysis was done using generalized linear model