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. 2021 Nov 6;12(11):1056. doi: 10.1038/s41419-021-04117-5

Fig. 7. EPC-derived EVs carrying TUG1 alleviate multiple organ damage induced by sepsis.

Fig. 7

A The survival rate of mice within 7 days after CLP analyzed by Kaplan–Meier analysis. B Measurement of creatinine, BUN, NGAL, AST, and ALT levels in mouse serum. C Serum levels of IL-6, TNF-α, and MCP-1 assessed by ELISA 24 h after surgery. D Pulmonary edema in mice assessed by the wet/dry ratio. E The measurement of blood vessel leakage in lung and liver of mice by injecting Evans blue dye. F The morphological changes of lung, liver, and kidney tissues observed by HE staining 24 h after CLP. Measurement data were expressed as mean ± standard deviation. One-way ANOVA was adopted for comparison between multiple groups followed by Tukey’s post hoc test. Kaplan–Meier analyses were performed to calculate the survival rate. Log-rank test was conducted for univariate survival analysis. *p < 0.05 vs. sham-operated mice; #p < 0.05 vs. CLP-operated mice treated with Ad-NC (n = 12).