Fig. 1.

Histopathology and Immunohistochemistry of hamster lungs. (a–h) Representative H&E images of lungs of hamsters infected with 10⁵ TCID₅₀ of ancestral, B.1.1.7, and B.1.351 variants at 4 days post-challenge (DPC). Foci of interstitial pneumonia and bronchiolitis were observed throughout all evaluated lung lobes of infected hamsters. (a-d) 40x, scale bar 500 μm. (e–h) 200x, scale bar 100 μm. (i–l) Immunohistochemistry (IHC) detected SARS-CoV-2 nucleocapsid staining in the lungs of all infected hamsters. 400x, scale bar 50 μm.