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Humoral immune response in challenged hamsters. Serum samples were collected at 14 and 28 DPC and by ELISA. (a) Total SARS-CoV-2 S-specific IgG and (b) RBD-specific IgG are shown. Cross-variant and homologous neutralization was assessed against (c) ancestral, (d) B.1.1.7, and (e) B.1.351 viruses. Line indicates limit of detection. Geometric mean and SD are depicted; statistical significance (Mann-Whitney) is indicated **p < 0.01 and *p < 0.05.
