Fig. 7.

Results of the region-of-interest (ROI) analysis for the prestimulation trials within a left and right amygdala mask. Parameter estimates for the look and decrease conditions are plotted separately for the negative and positive pictures and for the healthy controls and major depressive disorder (MDD) patients. Healthy controls showed a significant down-regulation effect of negative pictures within the right amygdala, t(17) = 2.69, p = 0.008; the effect did not reach statistical significance for the left amygdala, t(17) = 1.79, p = 0.046. The amount of downregulation in the left amygdala of healthy controls during processing of negative pictures was positively correlated with the participants’ reappraisal score (r = 0.50, p = 0.035). The amount of down-regulation in the right amygdala of MDD patients during processing of positive pictures was not significantly correlated with their BDI score (r = −0.39, p = 0.11). * p < .01; ** p < .001, FDR-corrected for multiple comparisons at FDR = .05 with a corrected critical p value of .01 (Benjamini-Hochberg, 1995)