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. 2021 Nov 6;21:347. doi: 10.1186/s12890-021-01726-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Effect of both HB-EGF-BEAS-2B-CM and HB-EGF-HBE-CM on proliferation and migration of human lung fibroblasts. CCK-8 assay was measured fibroblasts proliferation. Fibroblasts were cultured with various concentrations of HB-EGF-BEAS-2B (a) and HB-EGF-HBE-CM (b) for 24 h and 48 h. Besides, we used the transwell migration assay to assess the migration capability of fibroblasts. Lung fibroblasts were stimulated with 30% CM of BEAS-2B cells (c, d) and HBECs (e, f) for 24 h. Data are from one experiment representative of three independent experiments. Results are expressed as mean ± SEM. ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 versus control medium of BEAS-2B cells; **P < 0.01, ***P < 0.001 versus control medium of HBECs