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Peptide presentation threshold mechanism in BSCR. An increased expression of ERAP2 and a decreased expression of ERAP1, in addition to two copies of Aw19 alleles, increased the risk for BSCR (left), whereas decreased expression of ERAP2 and increased expression of ERAP1, in the presence of one copy of the A29 allele, decreased the risk for BSCR (right).
